The development of siRNAs has received a lot of interest from researchers as a result of FDA-approved siRNAs, and the design of siRNA delivery systems is a key challenge for further clinical applications. Therefore, antibody siRNA conjugates have emerged as potential carriers for targeted siRNA delivery. BOC Sciences is able to provide antibody siRNA conjugation services to meet your unique project needs. Our scientific team will work with you to create a scope of work to complete the project on time and within specifications.

Find out more with Drug Conjugation Services.

What is siRNA?
Small interfering RNA (siRNA) is a kind of macromolecular drugs with a molecular weight of approximately 13 kDa belonging to a family of small non-encoding ribonucleic acid (sncRNA). siRNAs, as double-stranded RNAs, suppress protein translation by recruiting RNA-induced silencing complex (RISC) to mRNA via Watson-Crick base pairing. siRNAs can target and silence aimed gene expression such as oncogenes, tumor suppressor genes and other regulatory genes by specific sequence recognition with mRNA. Despite advances siRNA-based therapies, low delivery efficiency and limited bio-barriers penetrability (owing to its strong negative charge and hydrophilic property) appear to be major obstacles for targeted siRNA therapeutics.

What are Antibody siRNA Conjugates?
Antibody-siRNA conjugate (ARC), an emerging siRNA drug delivery strategy, can overcome the current barriers in siRNA delivery. Inspired by the concept of ADC , ARC consists of the ligand (antibody) and the warhead (siRNA). ARCs can be produced by conjugating siRNA directly with multiple chemical groups in the antibody. Classical ARCs are prepared mainly based on the natural lysine residues in natural antibody or the cysteine residues reduced from the interchain disulfide bonds. Common conjugation methods involved in ARCs include Sulfhydryl and maleimide reaction, Amino and β-lactam ring-opening reaction, Biotin and avidin affinity reaction, etc. In addition, the antibody and siRNA also can be combined through electrostatic interactions, which has not been as widely used as chemical conjugation methods.

Our Services for Antibody siRNA Conjugates
Custom siRNA design
Custom siRNA synthesis
High throughput siRNA screening
Site-specific chemically modified siRNA
Conjugation methods and linkers optimization
Antibody siRNA conjugates
siRNA delivery
Ralated siRNA Conjugation
GalNAc-siRNA
Cholesterol conjugated siRNA
Fluorescent labeled siRNA
Liposome siRNA
Applications of Antibody siRNA Conjugates
Antibody-mediated siRNA delivery systems can be a promising choice. For example, siRNAs have been delivered to extrahepatic tissues using ARCs. These conjugates with low immunity can achieve pretty therapeutic effects and their simple prepare process make them closer to clinical transform.

siRNA has great application prospects in treatments of varies diseases. siRNAs can be conjugated with antibodies for treating cancer such as breast cancer, prostate cancer, colon cancer, or other diseases such as HIV and leukemia.

Our Advantages

Different ARC structures and batch development experience
Various conjugation methods through chemical modification or noncovalent interactions
A wide range of characteristic analysis
People and suites that specialize in ARC development, manufacturing, and testing
Data analysis, detailed report with results and discussion
Cost-effective and high-quality products

Source: https://bioconjugation.bocsci.com/services/antibody-sirna-conjugation-arc.html