Tumor Necrosis Factor (TNF) Inhibitor Drugs Market Size And Forecast

Tumor Necrosis Factor (TNF) Inhibitor Drugs Market size was valued at USD 39.55 Billion in 2020 and is projected to reach USD 41.63 Billion by 2028, growing at a CAGR of 0.64 % from 2021 to 2028.

The increasing prevalence of autoimmune illnesses around the world is driving the market’s expansion. Furthermore, rising public awareness about TNF is projected to boost the market forward. The Global Tumor Necrosis Factor (TNF) Inhibitor Drugs Market report provides a holistic evaluation of the market. The report offers a comprehensive analysis of key segments, trends, drivers, restraints, competitive landscape, and factors that are playing a substantial role in the market.

Global Tumor Necrosis Factor (TNF) Inhibitor Drugs Market Definition

TNF inhibitors are pharmaceutical drugs that block the physiologic response to tumor necrosis factors, such as the inflammatory response triggered by TNF cytokines. TNF-alpha, a key component of the autoimmune system, is responsible for inflammation in the body. Antibodies produced in a lab from human or animal tissue are TNF inhibitors. When they’re injected into human blood, they trigger an immune system reaction that prevents inflammation. Tumor necrosis factor is a chemical produced by the immune system. According to the National Center for Biotechnology Information (NCBI), Etanercept was the first anti-tumor necrosis factor (TNF) drug licensed by the Food and Drug Administration to treat rheumatoid arthritis.

Anti-TNF medicines are approved by the FDA to treat a variety of disorders, but they are also used off-label to treat graft-vs-host disease, pustular psoriatic, sarcoidosis, and Behcet disease. Tumor necrosis factor (TNF) is involved in the pathophysiology of several inflammatory diseases, including rheumatoid arthritis (RA). TNF is produced primarily by activated macrophages within the cell. After proteolysis by the TNF-converting enzyme, the precursor TNF is transformed to soluble TNF. The physiologically active homotrimer TNF is formed when the soluble TNF oligomerizes. TNF-alpha and TNF-beta are two kinds of TNF that are extremely closely related.

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Both TNFs exert their effects via binding to TNF receptors I and II (TNFRI and TNFRII), which are found on nearly all cell types (except erythrocytes). TNF activates multiple signaling pathways when it binds to TNFRI and TNFRII, including transcription factor activation (nuclear factor-B), proteases (caspases), and protein kinases (c-Jun N-terminal kinase, MAP kinase). This signaling causes the target cell to become activated, triggering an inflammatory and immunological response as well as the commencement of the apoptotic pathway. TNF’s biological effects include activation of other cells (macrophages, T-cells, B-cells), production of proinflammatory cytokines (IL-1, IL-6), chemokine production (IL-8, RANTES), expression of adhesion molecules (ICAM-1, E-selectin), inhibition of regulatory T-cells, upregulation of RANK-ligand expression, matrix metalloproteinase production, and apoptosis.

Global Tumor Necrosis Factor (TNF) Inhibitor Drugs Market Overview

The global rise in the healthcare industry is propelling the market for tumor necrosis factor (TNF) inhibitor pharmaceuticals to new heights. TNF inhibitors are a class of medications that are commonly used to reduce inflammation. These inhibitors are mainly generated from antibodies from human or animal tissues and are used to treat disorders such as ulcerative colitis, rheumatoid arthritis, plaque psoriasis, and Crohn’s disease. These medications are injected into the bloodstream to stimulate the immune system and reduce inflammation. One of the primary factors driving the growth of the Tumor Necrosis Factor (TNF) Inhibitor Drugs Market is the rise in the number of patients suffering from Crohn’s disease around the world.

According to the Crohn’s & Colitis Foundation (CCF), 1.6 million Americans have inflammatory bowel disease (IBD), with 70,000 new cases diagnosed each year. Crohn’s disease is a form of inflammatory bowel illness that affects the intestines (IBD). TNF inhibitors are used to suppress the inflammatory response induced by TNF cytokines, and they are widely used to treat inflammatory and autoimmune disorders such as psoriasis, cancer, and Crohn’s disease, among others. The market is also influenced by an increase in the number of research and development efforts in tumor necrosis factor (TNF) inhibitor medications, as well as a shift in the treatment of autoimmune illnesses due to biologics’ focused action and the appearance of biosimilars.

However, factors such as the high cost of rheumatoid arthritis treatment and products, as well as a lack of R&D activities, limit the growth of the tumor necrosis factor inhibitor market. The market for tumor necrosis factor inhibitors has a number of opportunities, including favorable government initiatives such as reimbursement policies, increased R&D activities for the launch of advanced products, and increased public awareness of technologically advanced treatment and product development. Adalimumab is a monoclonal antibody and disease-modifying antirheumatic medication that acts by inactivating tumor necrosis factor-alpha (TNF). Adalimumab and infliximab have been approved for the treatment of moderately to highly active Crohn’s disease in adults who have failed to respond to a full and appropriate course of corticosteroid and immunosuppressant therapy.

TNF inhibitors are an important and promising group of current medications with the potential to be used in a variety of disorders whose pathophysiology is linked to the immune system, due to TNF’s specific role in the initiation and maintenance of inflammatory reactions. The efficacy of these drugs has been demonstrated in authorized indications such as rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn’s disease, ulcerative colitis, and plaque psoriasis.

Global Tumor Necrosis Factor (TNF) Inhibitor Drugs Market: Segmentation Analysis

The Global Tumor Necrosis Factor (TNF) Inhibitor Drugs Market is Segmented on the basis of Product, Application, And Geography.

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Tumor Necrosis Factor (TNF) Inhibitor Drugs Market, By Product

• Humira
• Enbrel
• Remicade
• Simponi/Simponi Aria
• Cimzia
• Biosimilars

Based on Product, The market is segmented into Humira, Enbrel, Remicade, Simponi/Simponi Aria, Cimzia, and Biosimilars. Humira is used to treat a variety of inflammatory diseases in both adults and children, including those linked with autoimmune illness. People with autoimmune illnesses frequently experience inflammation as a result of the activation of a protein called TNF, which can cause painful and unpleasant joint swelling, damage, and other forms of inflammation. Humira is a drug that has been approved by the FDA to treat inflammatory autoimmune diseases. Humira is an anti-inflammatory drug that is used to treat moderate to severe rheumatoid arthritis. It works by identifying and suppressing the source of the inflammation that causes joint discomfort and damage.

Tumor Necrosis Factor (TNF) Inhibitor Drugs Market, By Application

• Rheumatoid Arthritis
• Psoriasis
• Psoriatic Arthritis
• Crohn’s Disease
• Ulcerative Colitis
• Ankylosing Spondylitis
• Juvenile Idiopathic Arthritis
• Hidradenitis Suppurativa
• Others

Based on Application, The market is segmented into Rheumatoid Arthritis, Psoriasis, Psoriatic Arthritis, Crohn’s Disease, Ulcerative Colitis, Ankylosing Spondylitis, Juvenile Idiopathic Arthritis, Hidradenitis Suppurativa, and Others. Rheumatoid arthritis (RA) is a chronic (long-term) condition that causes joint inflammation. Inflammation can be so severe that it alters the appearance and function of joints and other bodily parts. RA can develop abnormalities in the joints of the fingers in the hand. Psoriasis is an inflammatory disease caused by an immune-mediated disease. Psoriasis can arise on the eyelids, ear, lip, skin folds, hands, feet, and nails, among other places on the body. Plaques might damage a single little patch or a big area. Psoriasis plaques and scales can appear in multiple places on the body at the same time.

Tumor Necrosis Factor (TNF) Inhibitor Drugs Market, By Geography

• North America
• Europe
• Asia Pacific
• Rest of the world

On the basis of Geography, The market is classified into North America, Europe, Asia Pacific, and the Rest of the world. The Asia Pacific region is expected to witness a significant CAGR during the forecast period.

Key Players

The “Global Tumor Necrosis Factor (TNF) Inhibitor Drugs Market” study report will provide a valuable insight with an emphasis on the global market including some of the major players such as AbbVie Inc, Amgen Inc, Johnson & Johnson Services, Inc., UCB S.A., Novartis International AG, Pfizer, Inc., Merck & co., Inc., GlaxoSmithKline plc., and Bristol-Myers Squibb Company.

Our market analysis also entails a section solely dedicated to such major players wherein our analysts provide an insight into the financial statements of all the major players, along with its product benchmarking and SWOT analysis. The competitive landscape section also includes key development strategies, market share, and market ranking analysis of the above-mentioned players globally.

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