Tumor-killing Guinea Pig enzyme finally characterized, 60 years later
In order to express and purify bacterial and mammalian L-asparaginases for enzymatic and structural assays, these researchers ordered codon-optimized gene synthesis from GenScript.
Tumor-killing Guinea Pig enzyme finally characterized, 60 years later
After a 1953 paper revealed that guinea pig serum could kill tumor cells through L-asparaginase activity, several bacterial L-aspariginases were developed as FDA-approved drugs to treat acute lymphoblastic leukemia (ALL) and other cancers. However, side effects persist due to off-target glutaminase activity and immunogenicity, so researchers recently went back to the original source: the guinea pig. 60 years after that first report, they've now characterized a guinea pig enzyme they say should replace currently-used cancer drugs;
In order to express and purify bacterial and mammalian L-asparaginases for enzymatic and structural assays, these researchers ordered codon-optimized gene synthesis from GenScript. See how GenScript can accelerate your research:
Gene Synthesis starting at only $0.23/bp for 100% sequence-verified clonal DNA
Free Codon Optimization with our patented algorithm boosts soluble protein expression 100-fold.
New Express Cloning Service – get expression-ready clones for just $49 and 2 days added to your gene synthesis order.
After a 1953 paper revealed that guinea pig serum could kill tumor cells through L-asparaginase activity, several bacterial L-aspariginases were developed as FDA-approved drugs to treat acute lymphoblastic leukemia (ALL) and other cancers. However, side effects persist due to off-target glutaminase activity and immunogenicity, so researchers recently went back to the original source: the guinea pig. 60 years after that first report, they've now characterized a guinea pig enzyme they say should replace currently-used cancer drugs;
In order to express and purify bacterial and mammalian L-asparaginases for enzymatic and structural assays, these researchers ordered codon-optimized gene synthesis from GenScript. See how GenScript can accelerate your research:
Gene Synthesis starting at only $0.23/bp for 100% sequence-verified clonal DNA
Free Codon Optimization with our patented algorithm boosts soluble protein expression 100-fold.
New Express Cloning Service – get expression-ready clones for just $49 and 2 days added to your gene synthesis order.
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- Tumor-killing Guinea Pig enzyme finally characterized, 60 years later
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- Last Updated
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