According to the deep-dive market assessment study by Growth Plus Reports, the global transplantation market was valued at US$ 14.92 billion in 2022 and is expected to register a revenue CAGR of 9.47% to reach US$ 33.68 billion by 2031.

Transplantation Market Fundamentals

Transplantation, or organ transplantation, is a medical procedure in which a healthy organ or tissue is surgically removed from one person, known as the donor, and placed into another person, known as the recipient. Transplantation aims to replace a failing or damaged organ with a functional one, thereby improving or restoring the recipient's health and quality of life. Organ transplantation has become a life-saving option for individuals with end-stage organ failure, where other treatments have failed or are no longer effective. Common organs that can be transplanted include the heart, kidneys, liver, lungs, pancreas, and intestines. In addition, tissues such as corneas, skin, bone, and bone marrow can also be transplanted.

Transplantation has revolutionized medical care and significantly improved the survival rates and quality of life for many patients with organ failure. Efforts are ongoing to increase organ donation rates, promote organ sharing, and develop alternative approaches such as xenotransplantation and regenerative medicine techniques to address the shortage of organs.

Transplantation Market Dynamics

The prevalence of organ failure, such as end-stage renal disease, liver cirrhosis, heart failure, and lung disease, is rising globally. The growing incidence of these conditions fuels the demand for organ transplantation as a life-saving treatment option. According to the European Society of Cardiology, in the span of 1990-2017, the number of patients with heart failure doubled from 33.5 million to 64.3 million. Additionally, advances in surgical techniques, immunosuppressive medications, and organ preservation methods have improved the success rates of transplantation procedures. These advancements have made transplantation viable for a broader range of patients, increasing the demand for transplants and thus boosting the global transplantation market. Furthermore, efforts to expand the organ donor pool have contributed to the growth of the global transplantation market. This includes initiatives to increase deceased organ donation rates, living donor programs, and the use of extended criteria donors (ECDs) or marginal organs that may not have been considered suitable in the past.

However, the demand for organs far exceeds the available supply, leading to long waiting lists and significant challenges in organ allocation. The need for more organs restricts the number of transplantation procedures that can be performed and limits the market's growth potential. For instance, according to the Health Resources & Services Administration, each day, 17 individuals die while waiting for an organ transplant, and another person is added to the waiting list every 10 minutes. Transplantation procedures are complex and expensive, involving pre-operative evaluations, surgical procedures, post-operative care, immunosuppressive medications, and long-term follow-up. The high cost of transplantation can create financial barriers for patients, limiting access to transplantation and impacting market growth. Moreover, despite advancements in immunosuppressive medications, organ rejection remains a significant concern in transplantation. The recipient's immune system can recognize the transplanted organ as foreign and mount an immune response, potentially leading to organ failure. The need for lifelong immunosuppressive therapy can have side effects and complications, affecting patient outcomes. Additionally, organ shortage, rejection, and high procedure costs are some of the restraints impeding the overall market growth.

Transplantation Market Ecosystem

The global transplantation market is analyzed from the following perspectives: products, application, end user, and region.

Transplantation Market by Products

Based on the products, the global transplantation market is segmented into tissue products, preservation solutions, and immunosuppressive drugs.

The tissue products segment dominated the market with a principal revenue share of 55.4% in 2022. The increasing number of transplantation procedures, such as cochlear, heart valves, bone marrow, and orthopedic soft tissues, is attributed to the segment’s growth. Tissue products are the numerous forms of human tissues used for transplantation. Tissue transplantation involves specific tissues, such as corneas, skin, bone, tendons, and heart valves, rather than whole organs. These tissues are obtained from deceased donors and can be used to replace or repair damaged or diseased tissues in recipients. The availability of high-quality tissue grafts, advancements in tissue preservation techniques, and ongoing research and development in tissue engineering contribute to the segment's growth.

Transplantation Market by Application

Based on the application, the global transplantation market is segmented into tissue transplantation and organ transplantation.

The organ transplantation segment accounted for a prominent share of the market. Organ transplantation focuses on the transplantation of whole organs from deceased or living donors to recipients in need of organ replacement. Organ transplantation is a complex medical procedure involving the surgical removal of an organ from a donor and its implantation into the recipient's body. Organ transplant surgeries involve the transplantation of a whole organ, such as a heart, liver, kidney, lung, or pancreas, from the donor to the recipient. Highly skilled transplant surgeons lead the surgical procedures, often assisted by a specialized surgical team. The surgical techniques and protocols vary depending on the organ being transplanted. The organs for transplantation are obtained from deceased individuals who have consented to organ donation or living individuals who voluntarily donate an organ. Donor evaluation includes medical history review, physical examinations, and various tests to assess the health and suitability of the organs for transplantation. These factors contribute to the growth of the organ transplantation segment.

Transplantation Market by End User

Based on the end user, the global transplantation market is segmented into transplantation centers, hospitals, and others.

The hospitals segment is a key player in the transplantation market, with the largest revenue share of 51.2% in 2022, being the primary treatment center for the transplantation procedure. Hospitals play a crucial role in all aspects of the transplantation process, from patient evaluation and pre-transplant care to surgical procedures, post-operative care, and long-term follow-up. Hospitals that have specialized transplant centers are at the forefront of transplantation services. These centers typically have multidisciplinary teams consisting of transplant surgeons, transplant physicians, nurses, anesthesiologists, social workers, and other healthcare professionals collaborating to provide comprehensive care to transplant patients. Hospitals perform transplantation surgeries involving donor organs or tissue implantation into the recipient's body. Transplant surgeons lead the surgical procedures, working with a specialized surgical team to ensure the successful transplantation of the organ or tissue. Hospitals must maintain state-of-the-art surgical facilities and adhere to strict surgical protocols. These overall factors contribute to the growth of the hospital segment.

Transplantation Market by Region

Geographically, the global transplantation market has been segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.

North America dominated the global transplantation market with the largest revenue share of 41% in 2022, attributed to advanced healthcare infrastructure, robust research and development activities, and a high prevalence of transplantation procedures. For instance, according to the Organ Procurement and Transplantation Network, in the United States, 42,887 organ transplants were performed in 2022, setting a record. North America has well-established transplantation programs and centers of excellence that have significantly contributed to the field. These programs have extensive experience in organ transplantation, advanced surgical techniques, and comprehensive post-transplant care. The region has many transplant centres in academic institutions and private hospitals, providing various transplantation services.

Additionally, regional companies are continuously involved in partnerships, mergers, and acquisitions, which are also expected to improve the transplantation market outlook. For instance. North America is at the forefront of technological advancements in transplantation. The region has witnessed the development and adoption of innovative techniques, including minimally invasive surgeries, robotic-assisted surgeries, improved organ preservation methods, and advanced immunosuppressive therapies. These advancements have contributed to improved patient outcomes, shorter hospital stays, and reduced complications.

Transplantation Market Competitive Landscape

The prominent players operating in the global transplantation market are:
• Arthrex, Inc.
• Astellas Pharma
• Zimmer Biomet
• 21st Century Medicine
• Veloxis Pharmaceuticals Inc.
• BiolifeSolutions, Inc.
• Orthofix Medical Inc.
• Amnio Technology

Transplantation Market Strategic Developments

• In July 2022, Precise Bio partnered with Carl Zeiss Meditec to develop and commercialize tissue-based implants for ophthalmology. The firms will collaborate to create 4D bio-fabricated corneal transplants for patients requiring endothelial keratoplasty and natural lenticular transplants to treat keratoconus and vision correction.
• In February 2022, Amnio Technology, a global pioneer in the development and marketing of amniotic tissue allografts, introduced two new PalinGen membrane products, PalinGen Dual-Layer Membrane and Dual Layer PalinGen X-Membrane. Like the whole PalinGen membrane product line, the novel allografts are minimally modified, analogous in usage, and devoid of the chorion. The dual-layered structure of the allografts allows for unidirectional application with two epithelial sides facing outward. The PalinGen membranes are manufactured using the patented Advantek technology, which retains the extracellular matrix components and regulatory proteins found in amniotic tissues. Keeping the properties of natural tissue helps in wound treatment.

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