Oligonucleotide Synthesis Market: Overview and Segmentation

Oligonucleotide synthesis is a procedure by which nucleic acid biomolecules with definite sequences are synthetically made. Oligonucleotide synthesis is required for various life sciences research projects, from simple molecular biology research to even broader areas such as plant and animal studies, drug development, medical diagnosis, agriculture and food industry.

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The global oligonucleotide synthesis market is segmented on the basis of:
• Products
• End-users and
• Applications

On the basis of product, the global oligonucleotide synthesis market is broadly classified into reagent, probe, equipment, primer and synthesized oligonucleotide. Among these segments, the synthesized oligonucleotide market segment is likely to register the highest growth rate during the forecast period, due to the increasing number of its applications in research, therapeutics and diagnostics; and increasing demand for custom oligos in these applications.

On the basis of end-users, the global oligonucleotide synthesis market is further segmented into pharmaceutical and biotech firms, academic research institutes, and diagnostic laboratory. Demand from diagnostic laboratories is likely to grow rapidly among the end user segments during the forecast period owing to the adoption of new techniques such as polymerase chain reaction, real time polymerase chain reaction, DNA microarrays and others.

On the basis of applications, the global oligonucleotide synthesis market is segmented into research, therapeutics, and diagnostics. Research applications are further segmented into sequencing, gene synthesis, polymerase chain reaction (PCR), real-time quantitative polymerase chain reaction (qPCR) and others. Therapeutics market is further segmented into antisense oligos, RNAi, and others.

Oligonucleotide Synthesis Market: Drivers
The global oligonucleotide synthesis market is driven by various factors which include:
• Budding applications in molecular diagnostics and synthetic biology
• Increasing research & development spending in biotech and pharmaceutical companies
• Developing significance of RNA-interference oligos in diagnostics and therapeutics
• Venture capital funding and government spending are additional key factors that will enhance the growth of this market. For example, the U.S. National Institutes of Health (NIH) spends approximately USD1.5 billion annually to support their oligonucleotide-based applications including manual manipulation of DNA.

On the other hand, factors such as authoritarian barriers, downward pricing pressure of therapeutic oligos, may inhibit the growth of oligonucleotide synthesis market.

Oligonucleotide Synthesis Market: Region-wise Outlook

Geographically, the global oligonucleotide synthesis market is segmented into North America, Europe, Asia-Pacific (APAC) and Rest of the World. Asia-Pacific is hovering to grow rapidly due to increase in research and development activities, increasing R&D funding and rising accessibility of synthesized oligos in the region. Several major players are establishing their oligonucleotide manufacturing services in APAC to seize market opportunity in the region. For example, in July 2013, Integrated DNA Technologies, Inc. opened an oligonucleotide manufacturing unit in Singapore to provide oligonucleotide-based products to research companies in APAC, thereby establish its trail in the APAC market. Such expansion is further expected to drive growth in the APAC oligonucleotide synthesis market in the upcoming years.

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Oligonucleotide Synthesis Market: Key Players
Some of the key global market participants present in the Oligonucleotide Synthesis Market are Qiagen, GE Healthcare, BioAutomation Corporation, Glen Research, Eurofins Genomics, Integrated DNA Technologies, Inc., Thermo Fisher Scientific, Inc., Link Technologies, Ltd., Nitto Denko Avecia, Inc., TriLink Biotechnologies, Inc., Agilent Technologies, Inc., GenScript USA Inc., BioSearch Technologies, Inc., Eurogentec, Sigma-Aldrich Co. LLC, Gene Link, Inc., and GeneDesign, Inc. Competitiveness in the global oligonucleotide synthesis market has been growing continually and more and more companies have been moving into the niche Oligonucleotide market, resulting in price pressure Qiagen lately decided to trade off its nucleic acid synthesis unit because of these pricing pressures, but strategically retained its RNAi segment as this presented both high margin and high growth to the company.

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