It is very challenging to pin point the exact problem in the failure cases of IVF. Role of men sperm is very less in fertilization; sperm are the one which gives parent DNA to child. That is the reason for most of the men infertility cases are success with careful ICSI treatment. But most of the doctors claim that sperm DNA is the major cause for IVF failure. But it is entirely wrong. Assessing the endometrium is other kind of test, which are technically unproven. With our experience, we would say that egg is the major cause for IVF failure as it plays a major role in embryonic development. Sometimes it is very easy to know by performing cross testing, fertilized egg with sperm donor. But these tests are very complicated and some patients refuse for this. Many advanced technologies are there today to check sperm DNA fragmentation and endometrial function. But these tests have many deficiencies and are not same for every individual. Understandings for failure cases Fear is the main reason that most of the infertile couple refuses IVF treatment. IVF is mostly a trial and error method. The patients need to consult famous and experienced doctors in this case. There should be a perfect record of all the tests of the previous treatment like dose of the medicines used in the treatment, data regarding collection of eggs, quality and thickness of embryos and its information. Pictures of the embryo are very helpful for the new doctor, so that he/she can assess what went wrong in the treatment. The issues identified for the failure in the first attempt reduces the occurring of same in the second attempt. After the failure of first cycle, the success of second one is totally depends on the quality of eggs, depends on age, quality of sperm, lab quality in the hospital, experience of the doctor and genetic capability of embryo. If everything goes right, the chances of getting success in second and thirds IVF cycles are more. Our experienced doctors learn many of the useful things from IVF failure cases and are striving to avoid them in second phase. Being active after failure IVF is the most complex process as it involves dealing with emotions. The journey to the success of IVF is full of hurdles. Here are the some of the tips that makes you come out of the depression from IVF failure.