Many extremely potent and selective anthelmintics are available, but they must be used correctly, cautiously, and with consideration of the parasite/host interaction in order to provide a favourable clinical response, good control, and reduce anthelmintic resistance selection. Any reduction or increase in the approved dose rate must be avoided at all costs. Underdosing is likely to result in decreased efficacy and, potentially, greater pressure for resistance to develop. Overdosing can cause toxicity while also decreasing the efficacy of the substance.

Anthelmintics include imidazothiazoles, salicylanilides and modified phenols, tetrahydropyrimidines, benzimidazoles and probenzimidazoles, organophosphates, macrocyclic lactones, and, more recently, cyclic octadepsipeptides, amino-acetonitrile derivatives, and spiroindoles, among others. Although it may appear that chemotherapeutic control of helminth infections is currently adequate, parasite resistance selection is becoming a growing problem.

Centurion Healthcare is an excellent and reputed Anthelmintic drugs supplier in India.
What is Mebendazole?
Mebendazole is a synthetic benzimidazole with anthelmintic efficacy throughout a broad spectrum and a minimal risk of side effects. It is used to treat illnesses caused by roundworms, pinworms, whipworm eggs, and hookworms.
● Action Mechanism:
- Mebendazole works by preventing the formation of microtubules. It binds to parasite 13-tubulin and prevents it from polymerizing. Furthermore, mebendazole inhibits parasite glucose intake and depletes their glycogen stores.
- The drug's efficacy varies depending on gastrointestinal transit duration, the severity of illness, and possibly the parasite strain.

Centurion Healthcare is one of the most popular and distinguished Anthelmintic drugs exporters in India.
● Pharmacokinetics:
- Mebendazole has a low absorption rate in the intestines.
- Mebendazole is only absorbed around 10% of the time when taken orally. The medication is protein-bound (> 90%), quickly converted to inactive metabolites (mostly during the first pass through the liver), and has a half-life of 2-6 hours.
- 75–90% of the oral dosage was excreted in the faeces.

● Dosage:
- Chewable tablet containing 100 mg.
- Suspension of 100 mg/SML.
- Tablets of 100 mg
- Mebendazole is a favoured medicine for the treatment of various infestations and is more successful in the treatment of trichuriasis than albendazole.
What is Albendazole?
Albendazole is a broad-spectrum anthelmintic that can be used orally. For the treatment of hydatid illness and cysticercosis, it is the medication of choice. It's also used to treat roundworms, pinworms, whipworm, threadworm, and hookworms infections.

Roundworm, pinworm, and hookworm infections can be treated with just one dose, which is similar to three days of mebendazole treatment. Tapeworms, such as H. nana, require three days of therapy. It has a minor microfilaricidal effect. MOA is a drug that works similarly to mebendazole.

If you are looking for the best and leading Anthelmintic drugs exporter in India, Centurion Healthcare is the most preferred pharma company in the market for Anthelmintic drugs.
● Clinical Usage:
- When treating intraluminal parasites, albendazole is given on an empty stomach, while when treating tissue parasites, it is given with a fatty meal.
- Infections caused by trichuriasis, ascariasis, pinworm, and hookworm: 400 mg oral/adult and children older than 2 years.
- Adjunct to surgical excision or aspiration of cysts for Hydatid illness. For one month or longer, take 400 mg Albendazole 2 times a day after meals.
- Corticosteroids are used in conjunction with an anthelmintic medication to reduce inflammation induced by dying organisms in Neurocysticercosis. Albendazole can be taken twice a day for up to 21 days at a dose of 400 mg.
- Treatment of cutaneous larva migrans needs 400 mg Albendazole a day for 3 days; visceral larva migrans needs 400 mg Albendazole 2 times a day for 5 days; microporidial infection needs 400 mg Albendazole 2 times a day for 2 weeks; gnathostomiasis needs 400 mg Albendazole 2 times a day for 3 weeks.

● Pharmacokinetics:
- Albendazole is poorly absorbed following oral delivery, although a high-fat meal improves absorption.
- It is predominantly eliminated in the urine after being processed in the liver.
- The approximate time for the Albendazole to start working is around 8.5 hours.